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The microbial metabolite itaconate reduces Th17 differentiation and promotes Treg generation by inhibiting both glycolysis and OXPHOS (173)

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A comprehensive treatment strategy broadly effective in epilepsy may therefore involve a combinational approach of ASMs coupled with GSH inducing and nrf2 activating compounds

The enzyme is also thought to be responsible for the hydrolysis of some -lactam antibiotics such as perem and carbaperem (Campbell et al., 1984)

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Fluorescence microscopy Fluorescence was observed by using the laser scanning confocal microscope LSM FV1000 (Olympus)